Zoloft Withdrawal Solution, Sertraline Side Effects, Treatment Options
Zoloft Withdrawal Symptoms
The majority of people attempting Zoloft withdrawal experience an antidepressant
withdrawal syndrome. This is also known as Zoloft discontinuation syndrome in
the United States. In Europe it is call Zoloft withdrawal side effects. The F.D.A.
estimates 10% of those experiencing Zoloft withdrawal will go back up on the
Zoloft because the withdrawal symptoms are too severe.
If you want to read the short version of how to handle Zoloft withdrawal side effects
Click here. Page opens new browser window.
The most common and debilitating Zoloft withdrawal side effect is called "brain
zaps." Brain zaps are described by people experiencing it as a; electrical jolt that
tends to run from base of the neck up into their head. Another side effect that tends
to run with brain zaps is a shiver, a feeling as your head is floating, dizziness,
and/or a whirling sensation in the head.
These symptoms can come in waves or even be persistent.
The good news; in 2002, our founder, Jim Harper, discovered the correct type of
Omega 3 taken in the right quantity will eliminate these devastating head
symptoms quickly. Usually within a couple of hours.
The body in a normal state uses the oil from our diet, specifically from omega 3
found in fish, to build and replenish the end point of areas in the brain that sends
and receives electrical signals. We are using easy to understand terminology here
so it is easy to understand. Let's leave the technical jargon to physicians.
These brain zaps have nothing to do with serotonin levels or other made up
reasons. It is simple really; our body works in a very natural way with how it uses
amino acids, proteins, fats in food and all other diet items to maintain a balance.
When you introduce any toxin that disrupts these processes the body reacts.
The most common Zoloft withdrawal symptoms reported include:
Flu like symptoms
Insomnia
Anxiety
Brain zaps
Tremors
Diarrhea
Vomiting
Increased suicidal ideation
Nausea
Headache
Mania
Hypomania
Ringing in the ears
Aggression
Confusion
Imbalance
Mood swings
Please note: These are the most common Zoloft withdrawal side effects but far
from all potential Zoloft withdrawal side effects.
There is a warning the FDA has put a black box warning on Zoloft.
WARNING: SUICIDAL THOUGHTS AND BEHAVIORSSee full
prescribing information for complete boxed warning. Antidepressants
increased the risk of suicidal thoughts and behaviorsin pediatric and young
adult patients (5.1) Closely monitor for clinical worsening and emergence of
suicidalthoughts and behaviors
You may have been prescribed Zoloft within a very short doctor visit. There was
no investigation into other life factors, lab testing, or any conversation about what
side effects might present. The failings of this approach may cause quite a burden
on the patient.
Depression, insomnia, anxiety, fibromyalgia, and other symptoms that Zoloft is
often prescribed for might stem from; diminished vitamin D levels, over active
JNK gene, specific proteins that need to be silenced, dietary concerns and food
allergies, mitochondrial dysfunction, neurotoxic accumulation, and many other
reasons. A full physical from an understanding physician is ideal, before
prescribing Zoloft.
Do Your Symptoms Require Zoloft?
The Road Back Program uses nutritional supplements to help with the Zoloft
withdrawal. Most people feel a very fast relief from the Zoloft withdrawal once
they begin taking the supplements and we feel the odds are high; if would have
taken nutritional supplements like these before starting the Zoloft you would have
been prescribed the Zoloft in the first place.
In 2007, Jim Harper was giving a speech to a group of psychiatrists in Ireland and
during his talk he mentioned his mother just passed away 30 days ago. He went on
to describe how he made sure to take his JNK Formula each day to help the body
cope with the stress being put on it do to his loss. He went on to say, "The JNK
Formula will not remove the emotional loss and how I feel but it will keep the
body strong during my time to grieve."
How Do You Survive Zoloft Withdrawal?
Surviving Zoloft withdrawal depends on what you do at this very moment. If you
keep doing the same thing you have been doing and you are in a heavy Zoloft
withdrawal, nothing will change for the positive, That is a given.
If you decide to do the Zoloft withdrawal as an inpatient in a drug rehab center
DO NOT DO THE 9 DAY PLAN BECAUSE THAT WHAT INSURANCE
ALLOWS. Over the past 22 years I have worked with far to many people who
were sold on a rehab facility, stayed the 9 days because insurance would only pay
for that amount of time. The unscrupulous facility took them off the Zoloft in 9
days as they promised and by the time the person got off the airplane after their
return home they were in full withdrawal. You can't do a Zoloft withdrawal in 9
days.
The Road Back Program can normally help you get back on your feet again
but the rehab facility approach of this type is not worth the price you will pay
mentally and physically.
You will find a few other outpatient Zoloft withdrawal programs on the internet
now and Jim Harper is not aware of one that will cause you harm like the rehab
facility's mentioned. However, every other program on the internet was trained by
Jim Harper years ago and they are doing what Jim Harper and The Road Back did
during that time frame. Almost 2 decades ago Jim Harper trained several
physicians and good intentioned people how to get a patient off Zoloft. Jim went in
to detail of the process and what nutritional supplements were used and why they
were used. At that time of The Road Back the success rate was not as high as
desired and over the following years Jim changed the formulas used with the
supplements several times to use new information with DNA testing. Long story
short; you will likely wind up using a Zoloft withdrawal approach The Road Back
used in 2003, that was scrapped for something more successful.
If you are currently in Zoloft withdrawal, send Jim Harper an email and he will
personally guide you through the process so you can get back on your feet quickly
and have a very successful Zoloft withdrawal.
It does not matter if you have been on Zoloft for 1 month or 20 years. Recovery
can happen and the good part is; it does not take more time because you have been
taking Zoloft for years.
When Do Zoloft Withdrawal Symptoms Start When Discontinuing / Quitting
Zoloft?
Zoloft withdrawal usually begins between day 1 and day 3 of adjusting the Zoloft.
For some people this is not the case but eventually most everyone hits some dosage
of the Zoloft when reducing that jars them. Zoloft withdrawal begins and they have
no idea what they should do. Their physician does not know what to do. They wind
up in a spiral downward and wind up on a new medication to try and stop the
Zoloft withdrawal. The best case is the additional drug does that but you are now
on 2 drugs instead of only Zoloft.
What is Zoloft?
Zoloft (sertraline) is an antidepressant medication developed in the 1970s
with
FDA approval granted in 1991. This SSRI drug is prescribed in treating adult
depressive disorders (MDD), panic disorder, obsessive compulsory disorders
(OCD), social anxiety (SAD), post-traumatic stress disorders (PTSD), and
premenstrual dysphoric disorder (PMDD).
If you have anxiety before taking Zoloft, or anxiety begins while taking Zoloft,
odds are the anxiety will continue to get worse. Zoloft alters dopamine much like
the antidepressant Effexor and anxiety is a byproduct of these two drugs.
What Is Zoloft Used For?
Zoloft (sertraline) is an antidepressant medication approved to treat adult MDD
(major depressive disorder). The Black Box warning on the drug’s packaging
mentions that the drug should not be prescribed to anyone under the age of 25, due
to heightened risk of suicide. There is an exception to this for patients under the
age of 25 who have been diagnosed with OCD (obsessive-compulsive disorder).
Potential suicidality is associated with all Zoloft and may be a concern leading to
consider Zoloft withdrawal, which is recommended to be done always under
medical or caregiver monitoring.
Adult-only approved uses for the drug provided in a clinical or treatment
setting include:
MDD: Major Depressive Disorder<
PTSD: Post-traumatic stress disorder
PD: Panic disorder
SAD: Social anxiety disorder
OCD: Obsessive-compulsive disorder
PMDD: Premenstrual dysphoric disorder
Zoloft Side Effects
The full list of Zoloft side effects is quite staggering. In 2004, Jim Harper used the
Freedom of Information Act to get the full list of Zoloft side effects. Jim received
the information and it is 500 sheets of letter size paper, single space, a number 10
font size, 3 columns per page. In other words, thousands of known potential Zoloft
side effects were disclosed.
Some of the other Zoloft and Zoloft withdrawal side effects:
Serotonin syndrome: A life-threatening condition requiring immediate
medical care in a hospital emergency clinic or ICU. Symptoms to watch
for include sudden fever, losing consciousness, inability to move or
speak, copious sweating, dilated pupils, chills, tremors, convulsions,
diarrhea, agitation, restlessness, racing heart, etc.
Suicidal thoughts (common)
Suicide attempt (common)
Hyperkinesis (muscle spasms, movement disorder)
Worsened depression
Aggression
Paranoia (rare)
Anxiety
Mania (common)
Convulsions
Unconsciousness
Coma
Teeth grinding
Akathisia (relentless internal restlessness and discomfort marked by
repeated motions, pacing, rocking, etc., that can lead to suicidal
thoughts as a means of relief)
Tachycardia (racing heart, even when the body is at rest)
Rash
Itching
Burning, crawling feeling in the skin
Fever
Tics, sudden jerky movements, myoclonus
Emotional blunting
Behavioral apathy, SSRI-induced-indifference
Pain on urination or difficulty urinating
Cloudy urine
Headache
Sexual impairments, i.e., anorgasmia, inability to ejaculate, lowered
libido
Mood swings
Pain around the eyes or eye sockets
Sleepiness
Bladder pain
Prickling skin sensation
Numbness
Sensory disturbances
Insomnia
Depersonalization (common)
Nervousness
Nightmares (paroniria)
Hostility
Nausea
Diarrhea
Weight gain
Some documented Zoloft birth defects and injuries include:
PPHN or persistent pulmonary hypertension of the newborn, a heart and
lung condition which can result in respiratory failure, decreased oxygen to
the brain, and multiple organ injuries.
Congenital Heart Defects connected to Zoloft and other SSRIs include
ventricular septal defects and atrial septal defects, also referred to as “holes
in the heart”, related to heart murmurs, suppressed appetite, breathing
difficulties, tiredness, inadequate growth, etc.
Increased Risk of Autism has been extensively reported but evidence has
not yet been considered conclusive enough for regulatory bodies to ban
prescribing to pregnant women.
Increased Risk of Clubfoot connected to SSRIs during pregnancy as
reported by NIMH, where sertraline exposure had the highest increase in
clubfoot of all SSRIs.
Increased risk of atrial/ventricular defects and craniosynostosis was
reported in a Canadian study from 1998 to 2010 and published in the June
2015 issue of the American Journal of Gynecology & Obstetrics.
Zoloft Withdrawal, What to Expect
If using The Road Back Program you should expect to feel a lot better within the
first couple days of the program. If you do nothing, expect to continue to feel as
you do now. Possibly worse as time goes on. The chance of feeling better if you do
nothing is nil.
In 1999, The Road Back only had people taper the Zoloft gradually and slowly.
They still suffered. Around 50% could get off the Zoloft but most went back on the
Zoloft because they continual Zoloft withdrawal side effects would not diminish or
go away.
We wish there was a better answer for you than the above but with working with
over 19 million people over the last 22 years, the truth is the truth. No way to water
it down to make it sound better.
Some may think it is just their depression returning but who would not feel
depressed if they were still going through Zoloft withdrawal months after stopping
the Zoloft.
We can't stress enough; what you do or do not do at this moment in time is critical
for your future. Take your time if at all possible. If you have brain zaps go buy any
omega 3 fish oil, even the wrong omega 3 fish oil will help somewhat.
While you read this you may want to pause and go take a walk. Look at the trees,
the sky or anything off in the distance. Getting your attention off your mind and
body may do wonders.
Keep this close to your heart; There is Hope and There is a Solution. We are
speaking directly to YOU.
A 30 day supply of the nutritional supplements will cost you around $80. If you
feel it is worth $80 to take a chance that all of this can go away in a couple of days,
then take that chance. Over the past 22 years many have sent an email to Jim
Harper and said they were not sure what to do about the Zoloft withdrawal. Even
after reading this information. The people that tried something else generally came
back within a few months and were in worse shape than before. We do not want
this to happen to you. But if is; Jim will still be here to assist.
Can Zoloft Make Depression Worse?
Common sense answers this question. If depression is one side effect of taking
Zoloft then Zoloft can cause depression. You do stand a greater chance of Zoloft
causing depression during withdrawal than while simply taking the Zoloft as
prescribed. The depression during Zoloft withdrawal can be due to the other Zoloft
withdrawal side effects you are experiencing. Who would not start to get depressed
if you have anxiety from morning to night, can't sleep and your head feels like it is
on fire.
Zoloft Aggression in Children
Children are more prone to aggression when taking Zoloft than adults. It occurs in
10-20% of children taking any SSRI antidepressant. Two clinical trials performed
by Pfizer, aggression was the most common reason noted for Zoloft
discontinuation.
Can You Get Addicted to Zoloft?
Yes and no. This is where Zoloft dependence is a matter of wording. Medically
speaking in the United States Zoloft is not addicting. In Europe it is viewed as
addicting. The bottom line is; Once you take Zoloft for 7 days the Zoloft has made
its way through your body. If your body no longer has the Zoloft in its system,
your body will react to the Zoloft being gone.
Much like a person that eats a lot a sweets every day. Your body will react when
the sweet substance is not present. Call it addicting, as we would, call it a
dependence as United States physicians will, it is what it is. If you do not provide
the substance the body reacts and you also have mental feelings that are not
positive. We can get into the insulin discussion etc, but we are only talking about a
substance being present and then not and the body and mind reacting in a negative
manner.
What is the difference between Zoloft and a Benzodiazepine?
Zoloft is an SSRI medication, an antidepressant, used to treat depression and
anxiety. Benzodiazepines are prescribed mainly for the treatment of anxiety and
panic disorders but also prescribed off-label to treat depression.
These two types drug have different chemical components and were designed to
work on different brain receptors and neurotransmitters, but some of their effects
can be seen to overlap. Benzodiazepines are thought to mainly affect GABA
transmission, which can slow the central nervous system to reduce anxiety, while
Zoloft is designed to block the reuptake of serotonin.
Benzodiazepines are known to be more prone to dependence/addiction than Zoloft.
While the withdrawal symptoms are similar between both drugs, Zoloft’s half-life
is 22-36 hours, and Benzodiazepines half-life is much lower. Benzodiazepines can
have more severe complications if abruptly stopped, including seizures. For safe
Benzodiazepine or Zoloft withdrawal, either of these drugs must be slowly tapered
to allow the central nervous system and neurochemistry to safely normalize.
Choosing to withdrawal from the Zoloft first or the benzodiazepine first needs to
be evaluated. Use Chapter 23, The Science to decide is part of that equation.
Depending on the benzodiazepine you may be taking with the Zoloft, if you reduce
the Zoloft first it may make you go into withdrawal on the benzodiazepine, even if
you did not reduce the benzodiazepine.
How long does Zoloft stay in your system after the last dosage?
Our founder, Jim Harper, made great strides with determining this question. Using
his DNA testing company in 2004-2005, Jim conducted hundreds of DNA tests to
determine how fast or slow medications took to metabolize. In roughly 34 percent
of the population the Zoloft can take as long as 48 hours to clear the body. In
others, as little as 8 hours can occur for the Zoloft to clear the body.
Depending on other habits you may have, Zoloft could clear faster or even take
more time than the 48 hours. If you smoke cigarettes and stop smoking while
taking Zoloft, the Zoloft dosage you are taking will decrease by 15%. On the other
side of this, if you start smoking while taking Zoloft, the Zoloft dosage will act as
though it is 15% higher than you think it is. This is because cigarettes induce an
enzyme used to metabolize Zoloft and anything using that same pathway will
shoot though much faster. Caffeine restricts that same enzyme, so if you start or
stop drinking coffee while taking Zoloft you will either go into withdrawal or feel
an overdose, even though you have not changed the Zoloft dosage.
This is why The Road Back Program wants you to not change smoking habits or
caffeine habits during the Zoloft taper.
Can you overdose on Zoloft?
Yes, it is definitely possible for Zoloft poisoning to occur. A substantial Zoloft
overdose requires emergency medical intervention to prevent major health
problems. This list of Zoloft overdose symptoms would be the same as those
Zoloft side effects listed above, but more severe.
According to the National Institute of Health (NIH), the use of intravenous
benzodiazepines is sometimes required during Zoloft overdose to prevent seizures.
Extra cooling measures must be used to reduce hyperthermia, always under the
direction of EMT or other medical staff attending to the patient.
Treatment for Zoloft Withdrawal
Zoloft has become one of the most frequently prescribed antidepressants in the US.
Of equal importance is that depressive disorders have become one of the most
frequently diagnosed conditions. These two facts together underscore two
important steps toward improved health:
Providing safe treatment programs for those who have decided on Zoloft
withdrawal, and
Offering drug-free options to regain natural mental health without the need
for prescription medications.
The Road Back Program was described by Dr. Hyla Cass M.D. in this way:
Here's an essential handbook on how to safely and more easily wean yourself
(under medical supervision) off the heavily over-prescribed psychotropic
medications. I have used the program with my patients and it works!" Hyla
Cass M.D. Author of Supplement Your Prescription
Send an email to Jim Harper by using the Contact link on the top of this page or
read How to Get Off Psychoactive Drugs Safely by Jim Harper and follow the
program for Zoloft withdrawal. Why Jim put his entire book on our website for
free is so you can instantly read the material and start this process if you are
ready now.
One last thing Jim asked us to provide at the bottom of each page of Zoloft
descriptions:
There is Hope and There is a Solution
REFERENCES
Bailey, L.B., Gregory, J.F., (1999). “Polymorphisms of methylenetetrahydrofolate
reductase and other enzymes: metabolic significance, risks and impact on folate
requirement.” J Nutr 129(5): 919-22.
Bailey, L.B., Gregory, J.F., (1999). “Folate metabolism and requirements.” J Nutr
129(4): 779-82.
Basile, V.S., Masellis, M., Potkin, S.G., Kennedy, J.L., Pharmacogenomics in
schizophrenia: the quest for individualized therapy. Hum Mol Genet. 2002 Oct
1;11(20):2517-30
Blaisdell, J., Mohrenweiser, H., Jackson, Ferguson, J., Coulter, S., Chanas, S.,
Chanas, B., Xi, T., Ghanayem, B., Goldstein, J.A. Identification and functional
characterization of new potentially defective alleles of human CYP2C19.
Pharmacogenetics. 2002 Dec;12(9):703-11.
Bosron, W.F., Ting-Kai, L., (1986). “Genetic polymorphism of human liver
alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism
and alcoholism.” Hepatology 6(3): 502 – 510.
Bradford, L.D., CYP2D6 allele frequency in European Caucasians, Asians,
Africans and their descendants. Pharmacogenomics. 2002 Mar;3 (2):229-43.
Brockmoller, J., et.al. Pharmacogenetic diagnosis of cytochrome P450
polymorphisms in clinical drug development and in drug treatment.
Pharmacogenetics. 2000:1:125-51.
Budziszewska B, Szymanska M, Leskiewicz M, Basta-Kaim A, Jaworska-Feil L,
Kubera M, Jantas D, Lason W. The decrease in JNK- and p38-MAP kinase activity
is accompanied by the enhancement of PP2A phosphate level in the brain of
prenatally stressed rats. J Physiol Pharmacol. 2010 Apr;61(2):207-15.
Carter CJ. Multiple genes and factors associated with bipolar disorder converge on
growth factor and stress activated kinase pathways controlling translation
initiation: implications for oligodendrocyte viability. Neurochem Int. 2007
Feb;50(3):461-90. Epub 2007 Jan 18. Review.
Ceriello, A., Giugliano, D., Quatraro, A., Lefebvre, P.J., Anti-oxidants show an
anti-hypertensive effect in diabetic and hypertensive subjects. Clin Sci
1991;81:739-42.
Chang, T.K., et al. Enhanced cyclophosphamide and ifosfamide activation in
primary human hepatocyte cultures: response to cytochrome P-450 inducers and
autoinduction by oxazaphosphorines. Cancer Res 1997; 57(10):1946-54.
Chango, A., Boisson, F., et al. (2000). “The effect of 677C-->T and 1298A-->C
mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase
activity in healthy subjects.” Br J Nutr 83(6): 593-6.
Charradi K, Sebai H, Elkahoui S, Ben Hassine F, Limam F, Aouani E. Grape Seed
Extract Alleviates High-Fat Diet-Induced Obesity and Heart Dysfunction by
Preventing Cardiac Siderosis. Cardiovasc Toxicol. 2011 Jan 14.
Cheng, T., Zhu, Z., et al. (2001). “Effects of multinutrient supplementation on
antioxidant defense systems in healthy human beings.” J Nutr Biochem 12(7): 388-
395.
Chida, M., Yokoi, T., Fukui, T., Kinoshita, M., Yokota, J., Kamataki, T., Detection
of three genetic polymorphisms in the 5’-flanking region and intron 1 of human
CYP1A2 in the Japanese population. Jpn J Cancer Res. 1999 Sep;90(9):899-902
Chistyakov, D. A., Savost’anov, et al. (2001). “Polymorphisms in the Mn-SOD
and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes
mellitus.” BMC Med Genet 2(1): 4.
Cosma, G., Crofts, F., et al. (1993). “Relationship between genotype and function
of the human CYP1A1 gene.” J Toxicol Environ Health 40(2-3): 309-16.
Cozza, K.L., Armstrong, S.C., Oesterheld, J.R., Drug Interaction principles for
Medical Practice. American Psychiatric Publishing Inc. (2003)
Chuang DM. Neuroprotective and neurotrophic actions of the mood stabilizer
lithium: can it be used to treat neurodegenerative diseases? Crit Rev Neurobiol.
2004;16(1-2):83-90. Review.
Das J et al. Acetaminophen induced acute liver failure via oxidative stress and JNK
activation: protective role of taurine by the suppression of cytochrome P450 2E1.
Free Radic Res. 2010; 44(3): 340-55.
Gao N, Budhraja A, Cheng S, Yao H, Zhang Z, Shi X. Induction of apoptosis in
human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-
terminal kinase.
Clin Cancer Res. 2009 Jan 1;15(1):140-9.
Ho, P.C., et al. Influence of CYP2C9 genotypes on the formation of a hepatotoxic
metabolite of valproic acid in human liver microsomes. Pharmacogenomics J 2003;
3(6):335-42.
Jeong SW, Kim LS, Hur D, Bae WY, Kim JR, Lee JH. Gentamicin-induced spiral
ganglion cell death: apoptosis mediated by ROS and the JNK signaling pathway.
Acta Otolaryngol. 2010 Jun;130(6):670-8.
Lam, Y.W.F., Gaedigk, A., Ereshefsy, L., et al: CYP2D6 inhibition by selective
serotonin reuptake inhibitors: analysis of achievable steady-state plasma
concentrations and the effect of ultrarapid metabolism at CYP2D6.
Pharmacotherapy 2002;22:1001-1006.
Lichtenstein AH, Appel LJ, Brands M et al. Diet and lifestyle recommendations
revision 2006: a scientific statement from the American Heart Association
Nutrition Committee. Circulation, 2006; 114: 82-96.
Lin CL, Lin JK. Epigallocatechin gallate (EGCG) attenuates high glucose-induced
insulin signaling blockade in human hepG2 hepatoma cells. Mol Nutr Food Res.
2008; 52(8): 930-9.
Liu H, Xiao Y, Xiong C, Wei A, Ruan J. Apoptosis induced by a new flavonoid in
human hepatoma HepG2 cells involves reactive oxygen species-mediated
mitochondrial dysfunction and MAPK activation. Eur J Pharmacol. 2011 Jan 15.
Madhyastha R, Madhyastha H, Nakajima Y, Omura S, Maruyama M. Curcumin
Facilitates Fibrinolysis and Cellular Migration during Wound Healing by
Modulating Urokinase Plasminogen Activator Expression. Pathophysiol Haemost
Thromb. 2010 Nov 12
Maheshwari A, Misro MM, Aggarwal A, Sharma RK, Nandan D. N-Acetyl-L-
cysteine counteracts oxidative stress and prevents H(2) O(2) induced germ cell
apoptosis through down-regulation of caspase-9 and JNK/c-Jun. Mol Reprod Dev.
2010 Dec 22. doi: 10.1002/mrd.21268.
Moon et al. Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation
of 3T3-L1 cells. Obesity (Silver Spring). 2007; 15(11): 2571-82.
Pan J, Xiao Q, Sheng CY, Hong Z, Yang HQ, Wang G, Ding JQ, Chen SD.
Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3)
attenuates dopaminergic neuronal damage in mouse model of Parkinson’s disease.
Neurochem Int. 2009 Jun;54(7):418-25. Epub 2009 Jan 29.
Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M.
The GABAA Receptor malpha?+ebetaS- Interface: A Novel Target for Subtype
Selective Drugs. J Neurosci. 2011 Jan 19;31(3):870-7
Romier-Crouzet B, Van De Walle J, During A, Joly A, Rousseau C, Henry O,
Larondelle Y, Schneider YJ. Inhibition of inflammatory mediators by polyphenolic
plant extracts in human intestinal Caco-2 cells. Food Chem Toxicol. 2009
Jun;47(6):1221-30. Epub 2009 Feb 20.
Spiliotaki M, Salpeas V, Malitas P, Alevizos V, Moutsatsou P. Altered
glucocorticoid receptor signaling cascade in lymphocytes of bipolar disorder
patients. Psychoneuroendocrinology. 2006 Jul;31(6):748-60. Epub 2006 Apr 18.
Stornetta RL, Zhu JJ. Ras and Rap Signaling in Synaptic Plasticity and Mental
Disorders. Neuroscientist. 2010 Apr 29.
Tian H, Zhang G, Li H, Zhang Q. Antio
xidant NAC and AMPA/KA receptor
antagonist DNQX inhibited JNK3 activation following global ischemia in rat
hippocampus. Neurosci Res. 2003 Jun;46(2):191-7.
Waltner-Low ME et al. Epigallocatechin gallate, a constituent of green tea,
represses hepatic glucose production. J Biol Chem. 2002; 277(38): 34933-40.
Wu H et al. JNK-dependent NFATc1 pathway positively regulates IL-13 gene
expression induced by (-)-epigallocatechin-3-gallate in human basophilic KU812
cells. Free Radic Biol Med. 2009; 47(7): 1028-38.
Wu N et al. Taurine prevents free fatty acid-induced hepatic insulin resistance in
association with inhiditing JNK1 activation and improving insulin signaling in
vitro. Diabetes Res Clin Pract. 2010; 90(3): 288-90.
Xie N, Wang C, Lin Y, Li H, Chen L, Zhang T, Sun Y, Zhang Y, Yin D, Chi Z.
The role of p38 MAPK in valproic acid induced microglia apoptosis. Neurosci
Lett. 2010 Sep 20;482(1):51-6. Epub 2010 Jul 16.
Xu Y, Hou XY, Liu Y, Zong YY. Different protection of K252a and N-acetyl-L-
cysteine against amyloid-beta peptide-induced cortical neuron apoptosis involving
inhibition of MLK3-MKK7-JNK3 signal cascades. J Neurosci Res. 2009
Mar;87(4):918-27.
Yaniv SP, Lucki A, Klein E, Ben-Shachar D. Dexamethasone enhances the
norepinephrine-induced ERK/MAPK intracellular pathway possibly via
dysregulation of the alpha2-adrenergic receptor: implications for antidepressant
drug mechanism of action. Eur J Cell Biol. 2010 Sep;89(9):712-22.
Zhang F, Lau SS, Monks TJ. The Cytoprotective Effect of N-acetyl-L-cysteine
against ROS-induced Cytotoxicity is Independent of its Ability to Enhance
Glutathione Synthesis. Toxicol Sci. 2010 Dec 6.
Zoloft Withdrawal Solution,
Sertraline Side Effects, Treatment
Options
Zoloft Withdrawal Symptoms
The majority of people attempting
Zoloft withdrawal experience an
antidepressant withdrawal syndrome.
This is also known as Zoloft
discontinuation syndrome in the
United States. In Europe it is call
Zoloft withdrawal side effects. The
F.D.A. estimates 10% of those
experiencing Zoloft withdrawal will
go back up on the Zoloft because the
withdrawal symptoms are too severe.
The most common and debilitating
Zoloft withdrawal side effect is called
"brain zaps." Brain zaps are
described by people experiencing it as
a; electrical jolt that tends to run from
base of the neck up into their head.
Another side effect that tends to run
with brain zaps is a shiver, a feeling
as your head is floating, dizziness,
and/or a whirling sensation in the
head.
If you want to read the short version
of how to handle Zoloft withdrawal
side effects Click here.
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These symptoms can come in waves
or even be persistent.
The good news; in 2002, our founder,
Jim Harper, discovered the correct
type of Omega 3 taken in the right
quantity will eliminate these
devastating head symptoms quickly.
Usually within a couple of hours.
The body in a normal state uses the
oil from our diet, specifically from
omega 3 found in fish, to build and
replenish the end point of areas in the
brain that sends and receives electrical
signals. We are using easy to
understand terminology here so it is
easy to understand. Let's leave the
technical jargon to physicians.
These brain zaps have nothing to do
with serotonin levels or other made up
reasons. It is simple really; our body
works in a very natural way with how
it uses amino acids, proteins, fats in
food and all other diet items to
maintain a balance. When you
introduce any toxin that disrupts these
processes the body reacts.
The most common Zoloft withdrawal
symptoms reported include:
Flu like symptoms
Insomnia
Anxiety
Brain zaps
Tremors
Diarrhea
Vomiting
Increased suicidal ideation
Nausea
Headache
Mania
Hypomania
Ringing in the ears
Aggression
Confusion
Imbalance
Mood swings
Please note: These are the most
common Zoloft withdrawal side
effects but far from all potential
Zoloft withdrawal side effects.
There is a warning the FDA has put a
black box warning on Zoloft.
WARNING: SUICIDAL
THOUGHTS AND
BEHAVIORSSee full prescribing
information for complete boxed
warning. Antidepressants increased
the risk of suicidal thoughts and
behaviorsin pediatric and young
adult patients (5.1) Closely monitor
for clinical worsening and
emergence of suicidalthoughts and
behaviors
You may have been prescribed Zoloft
within a very short doctor visit. There
was no investigation into other life
factors, lab testing, or any
conversation about what side effects
might present. The failings of this
approach may cause quite a burden on
the patient.
Depression, insomnia, anxiety,
fibromyalgia, and other symptoms
that Zoloft is often prescribed for
might stem from; diminished vitamin
D levels, over active JNK gene,
specific proteins that need to be
silenced, dietary concerns and food
allergies, mitochondrial dysfunction,
neurotoxic accumulation, and many
other reasons. A full physical from an
understanding physician is ideal,
before prescribing Zoloft.
Do Your Symptoms Require Zoloft?
The Road Back Program uses
nutritional supplements to help with
the Zoloft withdrawal. Most people
feel a very fast relief from the Zoloft
withdrawal once they begin taking the
supplements and we feel the odds are
high; if would have taken nutritional
supplements like these before starting
the Zoloft you would have been
prescribed the Zoloft in the first place.
In 2007, Jim Harper was giving a
speech to a group of psychiatrists in
Ireland and during his talk he
mentioned his mother just passed
away 30 days ago. He went on to
describe how he made sure to take his
JNK Formula each day to help the
body cope with the stress being put on
it do to his loss. He went on to say,
"The JNK Formula will not remove
the emotional loss and how I feel but
it will keep the body strong during my
time to grieve."
How Do You Survive Zoloft
Withdrawal?
Surviving Zoloft withdrawal depends
on what you do at this very moment.
If you keep doing the same thing you
have been doing and you are in a
heavy Zoloft withdrawal, nothing will
change for the positive, That is a
given.
If you decide to do the Zoloft
withdrawal as an inpatient in a drug
rehab center DO NOT DO THE 9
DAY PLAN BECAUSE THAT
WHAT INSURANCE ALLOWS.
Over the past 22 years I have worked
with far to many people who were
sold on a rehab facility, stayed the 9
days because insurance would only
pay for that amount of time. The
unscrupulous facility took them off
the Zoloft in 9 days as they promised
and by the time the person got off the
airplane after their return home they
were in full withdrawal. You can't do
a Zoloft withdrawal in 9 days.
The Road Back Program can
normally help you get back on your
feet again but the rehab facility
approach of this type is not worth
the price you will pay mentally and
physically.
You will find a few other outpatient
Zoloft withdrawal programs on the
internet now and Jim Harper is not
aware of one that will cause you harm
like the rehab facility's mentioned.
However, every other program on the
internet was trained by Jim Harper
years ago and they are doing what Jim
Harper and The Road Back did during
that time frame. Almost 2 decades ago
Jim Harper trained several physicians
and good intentioned people how to
get a patient off Zoloft. Jim went in to
detail of the process and what
nutritional supplements were used and
why they were used. At that time of
The Road Back the success rate was
not as high as desired and over the
following years Jim changed the
formulas used with the supplements
several times to use new information
with DNA testing. Long story short;
you will likely wind up using a Zoloft
withdrawal approach The Road Back
used in 2003, that was scrapped for
something more successful.
If you are currently in Zoloft
withdrawal, send Jim Harper an email
and he will personally guide you
through the process so you can get
back on your feet quickly and have a
very successful Zoloft withdrawal.
It does not matter if you have been on
Zoloft for 1 month or 20 years.
Recovery can happen and the good
part is; it does not take more time
because you have been taking Zoloft
for years.
When Do Zoloft Withdrawal
Symptoms Start When
Discontinuing / Quitting Zoloft?
Zoloft withdrawal usually begins
between day 1 and day 3 of adjusting
the Zoloft. For some people this is not
the case but eventually most everyone
hits some dosage of the Zoloft when
reducing that jars them. Zoloft
withdrawal begins and they have no
idea what they should do. Their
physician does not know what to do.
They wind up in a spiral downward
and wind up on a new medication to
try and stop the Zoloft withdrawal.
The best case is the additional drug
does that but you are now on 2 drugs
instead of only Zoloft.
What is Zoloft?
Zoloft (sertraline) is an antidepressant
medication developed in the 1970s
with FDA approval granted in 1991.
This SSRI drug is prescribed in
treating adult depressive disorders
(MDD), panic disorder, obsessive
compulsory disorders (OCD), social
anxiety (SAD), post-traumatic stress
disorders (PTSD), and premenstrual
dysphoric disorder (PMDD).
If you have anxiety before taking
Zoloft, or anxiety begins while taking
Zoloft, odds are the anxiety will
continue to get worse. Zoloft alters
dopamine much like the
antidepressant Effexor and anxiety is
a byproduct of these two drugs.
What Is Zoloft Used For?
Zoloft (sertraline) is an antidepressant
medication approved to treat adult
MDD (major depressive disorder).
The Black Box warning on the drug’s
packaging mentions that the drug
should not be prescribed to anyone
under the age of 25, due to heightened
risk of suicide. There is an exception
to this for patients under the age of 25
who have been diagnosed with OCD
(obsessive-compulsive disorder).
Potential suicidality is associated with
all Zoloft and may be a concern
leading to consider Zoloft withdrawal,
which is recommended to be done
always under medical or caregiver
monitoring.
Adult-only approved uses for the
drug provided in a clinical or
treatment setting include:
MDD: Major Depressive
Disorder<
PTSD: Post-traumatic stress
disorder
PD: Panic disorder
SAD: Social anxiety disorder
OCD: Obsessive-compulsive
disorder
PMDD: Premenstrual
dysphoric disorder
Zoloft Side Effects
The full list of Zoloft side effects is
quite staggering. In 2004, Jim Harper
used the Freedom of Information Act
to get the full list of Zoloft side
effects. Jim received the information
and it is 500 sheets of letter size
paper, single space, a number 10 font
size, 3 columns per page. In other
words, thousands of known potential
Zoloft side effects were disclosed.
Some of the other Zoloft and Zoloft
withdrawal side effects:
Serotonin syndrome: A life-
threatening condition
requiring immediate medical
care in a hospital emergency
clinic or ICU. Symptoms to
watch for include sudden
fever, losing consciousness,
inability to move or speak,
copious sweating, dilated
pupils, chills, tremors,
convulsions, diarrhea,
agitation, restlessness, racing
heart, etc.
Suicidal thoughts (common)
Suicide attempt (common)
Hyperkinesis (muscle spasms,
movement disorder)
Worsened depression
Aggression
Paranoia (rare)
Anxiety
Mania (common)
Convulsions
Unconsciousness
Coma
Teeth grinding
Akathisia (relentless internal
restlessness and discomfort
marked by repeated motions,
pacing, rocking, etc., that can
lead to suicidal thoughts as a
means of relief)
Tachycardia (racing heart,
even when the body is at rest)
Rash
Itching
Burning, crawling feeling in
the skin
Fever
Tics, sudden jerky
movements, myoclonus
Emotional blunting
Behavioral apathy, SSRI-
induced-indifference
Pain on urination or difficulty
urinating
Cloudy urine
Headache
Sexual impairments, i.e.,
anorgasmia, inability to
ejaculate, lowered libido
Mood swings
Pain around the eyes or eye
sockets
Sleepiness
Bladder pain
Prickling skin sensation
Numbness
Sensory disturbances
Insomnia
Depersonalization (common)
Nervousness
Nightmares (paroniria)
Hostility
Nausea
Diarrhea
Weight gain
Some documented Zoloft birth
defects and injuries include:
PPHN or persistent pulmonary
hypertension of the newborn, a
heart and lung condition which
can result in respiratory failure,
decreased oxygen to the brain,
and multiple organ injuries.
Congenital Heart Defects
connected to Zoloft and other
SSRIs include ventricular
septal defects and atrial septal
defects, also referred to as
“holes in the heart”, related to
heart murmurs, suppressed
appetite, breathing difficulties,
tiredness, inadequate growth,
etc.
Increased Risk of Autism has
been extensively reported but
evidence has not yet been
considered conclusive enough
for regulatory bodies to ban
prescribing to pregnant women.
Increased Risk of Clubfoot
connected to SSRIs during
pregnancy as reported by
NIMH, where sertraline
exposure had the highest
increase in clubfoot of all
SSRIs.
Increased risk of
atrial/ventricular defects and
craniosynostosis was reported
in a Canadian study from 1998
to 2010 and published in the
June 2015 issue of the
American Journal of
Gynecology & Obstetrics.
Zoloft Withdrawal, What to Expect
If using The Road Back Program you
should expect to feel a lot better
within the first couple days of the
program. If you do nothing, expect to
continue to feel as you do now.
Possibly worse as time goes on. The
chance of feeling better if you do
nothing is nil.
In 1999, The Road Back only had
people taper the Zoloft gradually and
slowly. They still suffered. Around
50% could get off the Zoloft but most
went back on the Zoloft because they
continual Zoloft withdrawal side
effects would not diminish or go
away.
We wish there was a better answer for
you than the above but with working
with over 19 million people over the
last 22 years, the truth is the truth. No
way to water it down to make it sound
better.
Some may think it is just their
depression returning but who would
not feel depressed if they were still
going through Zoloft withdrawal
months after stopping the Zoloft.
We can't stress enough; what you do
or do not do at this moment in time is
critical for your future. Take your
time if at all possible. If you have
brain zaps go buy any omega 3 fish
oil, even the wrong omega 3 fish oil
will help somewhat.
While you read this you may want to
pause and go take a walk. Look at the
trees, the sky or anything off in the
distance. Getting your attention off
your mind and body may do wonders.
Keep this close to your heart; There is
Hope and There is a Solution. We are
speaking directly to YOU.
A 30 day supply of the nutritional
supplements will cost you around
$80. If you feel it is worth $80 to take
a chance that all of this can go away
in a couple of days, then take that
chance. Over the past 22 years many
have sent an email to Jim Harper and
said they were not sure what to do
about the Zoloft withdrawal. Even
after reading this information. The
people that tried something else
generally came back within a few
months and were in worse shape than
before. We do not want this to happen
to you. But if is; Jim will still be here
to assist.
Can Zoloft Make Depression Worse?
Common sense answers this question.
If depression is one side effect of
taking Zoloft then Zoloft can cause
depression. You do stand a greater
chance of Zoloft causing depression
during withdrawal than while simply
taking the Zoloft as prescribed. The
depression during Zoloft withdrawal
can be due to the other Zoloft
withdrawal side effects you are
experiencing. Who would not start to
get depressed if you have anxiety
from morning to night, can't sleep and
your head feels like it is on fire.
Zoloft Aggression in Children
Children are more prone to aggression
when taking Zoloft than adults. It
occurs in 10-20% of children taking
any SSRI antidepressant. Two clinical
trials performed by Pfizer, aggression
was the most common reason noted
for Zoloft discontinuation.
Can You Get Addicted to Zoloft?
Yes and no. This is where Zoloft
dependence is a matter of wording.
Medically speaking in the United
States Zoloft is not addicting. In
Europe it is viewed as addicting. The
bottom line is; Once you take Zoloft
for 7 days the Zoloft has made its way
through your body. If your body no
longer has the Zoloft in its system,
your body will react to the Zoloft
being gone.
Much like a person that eats a lot a
sweets every day. Your body will
react when the sweet substance is not
present. Call it addicting, as we
would, call it a dependence as United
States physicians will, it is what it is.
If you do not provide the substance
the body reacts and you also have
mental feelings that are not positive.
We can get into the insulin discussion
etc, but we are only talking about a
substance being present and then not
and the body and mind reacting in a
negative manner.
What is the difference between
Zoloft and a Benzodiazepine?
Zoloft is an SSRI medication, an
antidepressant, used to treat
depression and anxiety.
Benzodiazepines are prescribed
mainly for the treatment of anxiety
and panic disorders but also
prescribed off-label to treat
depression.
These two types drug have different
chemical components and were
designed to work on different brain
receptors and neurotransmitters, but
some of their effects can be seen to
overlap. Benzodiazepines are thought
to mainly affect GABA transmission,
which can slow the central nervous
system to reduce anxiety, while
Zoloft
is designed to block the reuptake of
serotonin.
Benzodiazepines are known to be
more prone to dependence/addiction
than Zoloft. While the withdrawal
symptoms are similar between both
drugs, Zoloft’s half-life is 22-36
hours, and Benzodiazepines half-life
is much lower. Benzodiazepines can
have more severe complications if
abruptly stopped, including seizures.
For safe Benzodiazepine or Zoloft
withdrawal, either of these drugs must
be slowly tapered to allow the central
nervous system and neurochemistry to
safely normalize.
Choosing to withdrawal from the
Zoloft first or the benzodiazepine first
needs to be evaluated. Use Chapter
23, The Science to decide is part of
that equation. Depending on the
benzodiazepine you may be taking
with the Zoloft, if you reduce the
Zoloft first it may make you go into
withdrawal on the benzodiazepine,
even if you did not reduce the
benzodiazepine.
How long does Zoloft stay in your
system after the last dosage?
Our founder, Jim Harper, made great
strides with determining this question.
Using his DNA testing company in
2004-2005, Jim conducted hundreds
of DNA tests to determine how fast or
slow medications took to metabolize.
In roughly 34 percent of the
population the Zoloft can take as long
as 48 hours to clear the body. In
others, as little as 8 hours can occur
for the Zoloft to clear the body.
Depending on other habits you may
have, Zoloft could clear faster or even
take more time than the 48 hours. If
you smoke cigarettes and stop
smoking while taking Zoloft, the
Zoloft dosage you are taking will
decrease by 15%. On the other side of
this, if you start smoking while
taking Zoloft, the Zoloft dosage will
act as though it is 15% higher than
you think it is. This is because
cigarettes induce an enzyme used to
metabolize Zoloft and anything using
that same pathway will shoot though
much faster. Caffeine restricts that
same enzyme, so if you start or stop
drinking coffee while taking Zoloft
you will either go into withdrawal or
feel an overdose, even though you
have not changed the Zoloft dosage.
This is why The Road Back Program
wants you to not change smoking
habits or caffeine habits during the
Zoloft taper.
Can you overdose on Zoloft?
Yes, it is definitely possible for Zoloft
poisoning to occur. A substantial
Zoloft overdose requires emergency
medical intervention to prevent major
health problems. This list of Zoloft
overdose symptoms would be the
same as those Zoloft side effects
listed above, but more severe.
According to the National Institute of
Health (NIH), the use of intravenous
benzodiazepines is sometimes
required during Zoloft overdose to
prevent seizures. Extra cooling
measures must be used to reduce
hyperthermia, always under the
direction of EMT or other medical
staff attending to the patient.
Treatment for Zoloft Withdrawal
Zoloft has become one of the most
frequently prescribed antidepressants
in the US. Of equal importance is that
depressive disorders have become one
of the most frequently diagnosed
conditions. These two facts together
underscore two important steps
toward improved health:
Providing safe treatment
programs for those who have
decided on Zoloft withdrawal,
and
Offering drug-free options to
regain natural mental health
without the need for
prescription medications.
The Road Back Program was
described by Dr. Hyla Cass M.D.
in this way:
Here's an essential handbook on
how to safely and more easily
wean yourself (under medical
supervision) off the heavily over-
prescribed psychotropic
medications. I have used the
program with my patients and it
works!" Hyla Cass M.D. Author
of Supplement Your Prescription
Send an email to Jim Harper by
using the Contact link on the top of
this page or read How to Get Off
Psychoactive Drugs Safely by Jim
Harper and follow the program for
Zoloft withdrawal.
Why Jim put
his entire book on our website for
free is so you can instantly read the
material and start this process if
you are ready now.
One last thing Jim asked us to
provide at the bottom of each page
of Zoloft descriptions:
There is Hope and There is a
Solution
REFERENCES
Bailey, L.B., Gregory, J.F., (1999).
“Polymorphisms of
methylenetetrahydrofolate
reductase and other enzymes: metabolic
significance, risks and impact on folate
requirement.” J Nutr 129(5): 919-22.
Bailey, L.B., Gregory, J.F., (1999).
“Folate metabolism and requirements.” J
Nutr
129(4): 779-82.
Basile, V.S., Masellis, M., Potkin, S.G.,
Kennedy, J.L., Pharmacogenomics in
schizophrenia: the quest for
individualized therapy. Hum Mol Genet.
2002 Oct
1;11(20):2517-30
Blaisdell, J., Mohrenweiser, H., Jackson,
Ferguson, J., Coulter, S., Chanas, S.,
Chanas, B., Xi, T., Ghanayem, B.,
Goldstein, J.A. Identification and
functional
characterization of new potentially
defective alleles of human CYP2C19.
Pharmacogenetics. 2002 Dec;12(9):703-
11.
Bosron, W.F., Ting-Kai, L., (1986).
“Genetic polymorphism of human liver
alcohol and aldehyde dehydrogenases,
and their relationship to alcohol
metabolism
and alcoholism.” Hepatology 6(3): 502 –
510.
Bradford, L.D., CYP2D6 allele
frequency in European Caucasians,
Asians,
Africans and their descendants.
Pharmacogenomics. 2002 Mar;3 (2):229-
43.
Brockmoller, J., et.al. Pharmacogenetic
diagnosis of cytochrome P450
polymorphisms in clinical drug
development and in drug treatment.
Pharmacogenetics. 2000:1:125-51.
Budziszewska B, Szymanska M,
Leskiewicz M, Basta-Kaim A, Jaworska-
Feil L,
Kubera M, Jantas D, Lason W. The
decrease in JNK- and p38-MAP kinase
activity
is accompanied by the enhancement of
PP2A phosphate level in the brain of
prenatally stressed rats. J Physiol
Pharmacol. 2010 Apr;61(2):207-15.
Carter CJ. Multiple genes and factors
associated with bipolar disorder
converge on
growth factor and stress activated kinase
pathways controlling translation
initiation: implications for
oligodendrocyte viability. Neurochem
Int. 2007
Feb;50(3):461-90. Epub 2007 Jan 18.
Review.
Ceriello, A., Giugliano, D., Quatraro, A.,
Lefebvre, P.J., Anti-oxidants show an
anti-hypertensive effect in diabetic and
hypertensive subjects. Clin Sci
1991;81:739-42.
Chang, T.K., et al. Enhanced
cyclophosphamide and ifosfamide
activation in
primary human hepatocyte cultures:
response to cytochrome P-450 inducers
and
autoinduction by oxazaphosphorines.
Cancer Res 1997; 57(10):1946-54.
Chango, A., Boisson, F., et al. (2000).
“The effect of 677C-->T and 1298A-->C
mutations on plasma homocysteine and
5,10-methylenetetrahydrofolate
reductase
activity in healthy subjects.” Br J Nutr
83(6): 593-6.
Charradi K, Sebai H, Elkahoui S, Ben
Hassine F, Limam F, Aouani E. Grape
Seed
Extract Alleviates High-Fat Diet-Induced
Obesity and Heart Dysfunction by
Preventing Cardiac Siderosis. Cardiovasc
Toxicol. 2011 Jan 14.
Cheng, T., Zhu, Z., et al. (2001). “Effects
of multinutrient supplementation on
antioxidant defense systems in healthy
human beings.” J Nutr Biochem 12(7):
388-
395.
Chida, M., Yokoi, T., Fukui, T.,
Kinoshita, M., Yokota, J., Kamataki, T.,
Detection
of three genetic polymorphisms in the 5’-
flanking region and intron 1 of human
CYP1A2 in the Japanese population. Jpn
J Cancer Res. 1999 Sep;90(9):899-902
Chistyakov, D. A., Savost’anov, et al.
(2001). “Polymorphisms in the Mn-SOD
and EC-SOD genes and their relationship
to diabetic neuropathy in type 1 diabetes
mellitus.” BMC Med Genet 2(1): 4.
Cosma, G., Crofts, F., et al. (1993).
“Relationship between genotype and
function
of the human CYP1A1 gene.” J Toxicol
Environ Health 40(2-3): 309-16.
Cozza, K.L., Armstrong, S.C.,
Oesterheld, J.R., Drug Interaction
principles for
Medical Practice. American Psychiatric
Publishing Inc. (2003)
Chuang DM. Neuroprotective and
neurotrophic actions of the mood
stabilizer
lithium: can it be used to treat
neurodegenerative diseases? Crit Rev
Neurobiol.
2004;16(1-2):83-90. Review.
Das J et al. Acetaminophen induced
acute liver failure via oxidative stress
and JNK
activation: protective role of taurine by
the suppression of cytochrome P450
2E1.
Free Radic Res. 2010; 44(3): 340-55.
Gao N, Budhraja A, Cheng S, Yao H,
Zhang Z, Shi X. Induction of apoptosis
in
human leukemia cells by grape seed
extract occurs via activation of c-Jun
NH2-
terminal kinase.
Clin Cancer Res. 2009 Jan 1;15(1):140-
9.
Ho, P.C., et al. Influence of CYP2C9
genotypes on the formation of a
hepatotoxic
metabolite of valproic acid in human
liver microsomes. Pharmacogenomics J
2003;
3(6):335-42.
Jeong SW, Kim LS, Hur D, Bae WY,
Kim JR, Lee JH. Gentamicin-induced
spiral
ganglion cell death: apoptosis mediated
by ROS and the JNK signaling pathway.
Acta Otolaryngol. 2010 Jun;130(6):670-
8.
Lam, Y.W.F., Gaedigk, A., Ereshefsy,
L., et al: CYP2D6 inhibition by selective
serotonin reuptake inhibitors: analysis of
achievable steady-state plasma
concentrations and the effect of
ultrarapid metabolism at CYP2D6.
Pharmacotherapy 2002;22:1001-1006.
Lichtenstein AH, Appel LJ, Brands M et
al. Diet and lifestyle recommendations
revision 2006: a scientific statement
from the American Heart Association
Nutrition Committee. Circulation, 2006;
114: 82-96.
Lin CL, Lin JK. Epigallocatechin gallate
(EGCG) attenuates high glucose-induced
insulin signaling blockade in human
hepG2 hepatoma cells. Mol Nutr Food
Res.
2008; 52(8): 930-9.
Liu H, Xiao Y, Xiong C, Wei A, Ruan J.
Apoptosis induced by a new flavonoid in
human hepatoma HepG2 cells involves
reactive oxygen species-mediated
mitochondrial dysfunction and MAPK
activation. Eur J Pharmacol. 2011 Jan
15.
Madhyastha R, Madhyastha H, Nakajima
Y, Omura S, Maruyama M. Curcumin
Facilitates Fibrinolysis and Cellular
Migration during Wound Healing by
Modulating Urokinase Plasminogen
Activator Expression. Pathophysiol
Haemost
Thromb. 2010 Nov 12
Maheshwari A, Misro MM, Aggarwal A,
Sharma RK, Nandan D. N-Acetyl-L-
cysteine counteracts oxidative stress and
prevents H(2) O(2) induced germ cell
apoptosis through down-regulation of
caspase-9 and JNK/c-Jun. Mol Reprod
Dev.
2010 Dec 22. doi: 10.1002/mrd.21268.
Moon et al. Inhibitory effect of (-)-
epigallocatechin-3-gallate on lipid
accumulation
of 3T3-L1 cells. Obesity (Silver Spring).
2007; 15(11): 2571-82.
Pan J, Xiao Q, Sheng CY, Hong Z, Yang
HQ, Wang G, Ding JQ, Chen SD.
Blockade of the translocation and
activation of c-Jun N-terminal kinase 3
(JNK3)
attenuates dopaminergic neuronal
damage in mouse model of Parkinson’s
disease.
Neurochem Int. 2009 Jun;54(7):418-25.
Epub 2009 Jan 29.
Ramerstorfer J, Furtmüller R, Sarto-
Jackson I, Varagic Z, Sieghart W, Ernst
M.
The GABAA Receptor malpha?+ebetaS-
Interface: A Novel Target for Subtype
Selective Drugs. J Neurosci. 2011 Jan
19;31(3):870-7
Romier-Crouzet B, Van De Walle J,
During A, Joly A, Rousseau C, Henry O,
Larondelle Y, Schneider YJ. Inhibition
of inflammatory mediators by
polyphenolic
plant extracts in human intestinal Caco-2
cells. Food Chem Toxicol. 2009
Jun;47(6):1221-30. Epub 2009 Feb 20.
Spiliotaki M, Salpeas V, Malitas P,
Alevizos V, Moutsatsou P. Altered
glucocorticoid receptor signaling cascade
in lymphocytes of bipolar disorder
patients. Psychoneuroendocrinology.
2006 Jul;31(6):748-60. Epub 2006 Apr
18.
Stornetta RL, Zhu JJ. Ras and Rap
Signaling in Synaptic Plasticity and
Mental
Disorders. Neuroscientist. 2010 Apr 29.
Tian H, Zhang G, Li H, Zhang Q. Antio
xidant NAC and AMPA/KA receptor
antagonist DNQX inhibited JNK3
activation following global ischemia in
rat
hippocampus. Neurosci Res. 2003
Jun;46(2):191-7.
Waltner-Low ME et al. Epigallocatechin
gallate, a constituent of green tea,
represses hepatic glucose production. J
Biol Chem. 2002; 277(38): 34933-40.
Wu H et al. JNK-dependent NFATc1
pathway positively regulates IL-13 gene
expression induced by (-)-
epigallocatechin-3-gallate in human
basophilic KU812
cells. Free Radic Biol Med. 2009; 47(7):
1028-38.
Wu N et al. Taurine prevents free fatty
acid-induced hepatic insulin resistance in
association with inhiditing JNK1
activation and improving insulin
signaling in
vitro. Diabetes Res Clin Pract. 2010;
90(3): 288-90.
Xie N, Wang C, Lin Y, Li H, Chen L,
Zhang T, Sun Y, Zhang Y, Yin D, Chi Z.
The role of p38 MAPK in valproic acid
induced microglia apoptosis. Neurosci
Lett. 2010 Sep 20;482(1):51-6. Epub
2010 Jul 16.
Xu Y, Hou XY, Liu Y, Zong YY.
Different protection of K252a and N-
acetyl-L-
cysteine against amyloid-beta peptide-
induced cortical neuron apoptosis
involving
inhibition of MLK3-MKK7-JNK3 signal
cascades. J Neurosci Res. 2009
Mar;87(4):918-27.
Yaniv SP, Lucki A, Klein E, Ben-
Shachar D. Dexamethasone enhances the
norepinephrine-induced ERK/MAPK
intracellular pathway possibly via
dysregulation of the alpha2-adrenergic
receptor: implications for antidepressant
drug mechanism of action. Eur J Cell
Biol. 2010 Sep;89(9):712-22.
Zhang F, Lau SS, Monks TJ. The
Cytoprotective Effect of N-acetyl-L-
cysteine
against ROS-induced Cytotoxicity is
Independent of its Ability to Enhance
Glutathione Synthesis. Toxicol Sci. 2010
Dec 6.