REFERENCES
Bailey, L.B., Gregory, J.F., (1999). “Polymorphisms of methylenetetrahydrofolate
reductase and other enzymes: metabolic significance, risks and impact on folate
requirement.” J Nutr 129(5): 919-22.
Bailey, L.B., Gregory, J.F., (1999). “Folate metabolism and requirements.” J Nutr
129(4): 779-82.
Basile, V.S., Masellis, M., Potkin, S.G., Kennedy, J.L., Pharmacogenomics in
schizophrenia: the quest for individualized therapy. Hum Mol Genet. 2002 Oct
1;11(20):2517-30
Blaisdell, J., Mohrenweiser, H., Jackson, Ferguson, J., Coulter, S., Chanas, S.,
Chanas, B., Xi, T., Ghanayem, B., Goldstein, J.A. Identification and functional
characterization of new potentially defective alleles of human CYP2C19.
Pharmacogenetics. 2002 Dec;12(9):703-11.
Bosron, W.F., Ting-Kai, L., (1986). “Genetic polymorphism of human liver
alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism
and alcoholism.” Hepatology 6(3): 502 – 510.
Bradford, L.D., CYP2D6 allele frequency in European Caucasians, Asians,
Africans and their descendants. Pharmacogenomics. 2002 Mar;3 (2):229-43.
Brockmoller, J., et.al. Pharmacogenetic diagnosis of cytochrome P450
polymorphisms in clinical drug development and in drug treatment.
Pharmacogenetics. 2000:1:125-51.
Budziszewska B, Szymanska M, Leskiewicz M, Basta-Kaim A, Jaworska-Feil L,
Kubera M, Jantas D, Lason W. The decrease in JNK- and p38-MAP kinase activity
is accompanied by the enhancement of PP2A phosphate level in the brain of
prenatally stressed rats. J Physiol Pharmacol. 2010 Apr;61(2):207-15.
Carter CJ. Multiple genes and factors associated with bipolar disorder converge on
growth factor and stress activated kinase pathways controlling translation
initiation: implications for oligodendrocyte viability. Neurochem Int. 2007
Feb;50(3):461-90. Epub 2007 Jan 18. Review.
Ceriello, A., Giugliano, D., Quatraro, A., Lefebvre, P.J., Anti-oxidants show an
anti-hypertensive effect in diabetic and hypertensive subjects. Clin Sci
1991;81:739-42.
Chang, T.K., et al. Enhanced cyclophosphamide and ifosfamide activation in
primary human hepatocyte cultures: response to cytochrome P-450 inducers and
autoinduction by oxazaphosphorines. Cancer Res 1997; 57(10):1946-54.
Chango, A., Boisson, F., et al. (2000). “The effect of 677C-->T and 1298A-->C
mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase
activity in healthy subjects.” Br J Nutr 83(6): 593-6.
Charradi K, Sebai H, Elkahoui S, Ben Hassine F, Limam F, Aouani E. Grape Seed
Extract Alleviates High-Fat Diet-Induced Obesity and Heart Dysfunction by
Preventing Cardiac Siderosis. Cardiovasc Toxicol. 2011 Jan 14.
Cheng, T., Zhu, Z., et al. (2001). “Effects of multinutrient supplementation on
antioxidant defense systems in healthy human beings.” J Nutr Biochem 12(7): 388-
395.
Chida, M., Yokoi, T., Fukui, T., Kinoshita, M., Yokota, J., Kamataki, T., Detection
of three genetic polymorphisms in the 5’-flanking region and intron 1 of human
CYP1A2 in the Japanese population. Jpn J Cancer Res. 1999 Sep;90(9):899-902
Chistyakov, D. A., Savost’anov, et al. (2001). “Polymorphisms in the Mn-SOD
and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes
mellitus.” BMC Med Genet 2(1): 4.
Cosma, G., Crofts, F., et al. (1993). “Relationship between genotype and function
of the human CYP1A1 gene.” J Toxicol Environ Health 40(2-3): 309-16.
Cozza, K.L., Armstrong, S.C., Oesterheld, J.R., Drug Interaction principles for
Medical Practice. American Psychiatric Publishing Inc. (2003)
Chuang DM. Neuroprotective and neurotrophic actions of the mood stabilizer
lithium: can it be used to treat neurodegenerative diseases? Crit Rev Neurobiol.
2004;16(1-2):83-90. Review.
Das J et al. Acetaminophen induced acute liver failure via oxidative stress and JNK
activation: protective role of taurine by the suppression of cytochrome P450 2E1.
Free Radic Res. 2010; 44(3): 340-55.
Gao N, Budhraja A, Cheng S, Yao H, Zhang Z, Shi X. Induction of apoptosis in
human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-
terminal kinase.
Clin Cancer Res. 2009 Jan 1;15(1):140-9.
Ho, P.C., et al. Influence of CYP2C9 genotypes on the formation of a hepatotoxic
metabolite of valproic acid in human liver microsomes. Pharmacogenomics J 2003;
3(6):335-42.
Jeong SW, Kim LS, Hur D, Bae WY, Kim JR, Lee JH. Gentamicin-induced spiral
ganglion cell death: apoptosis mediated by ROS and the JNK signaling pathway.
Acta Otolaryngol. 2010 Jun;130(6):670-8.
Lam, Y.W.F., Gaedigk, A., Ereshefsy, L., et al: CYP2D6 inhibition by selective
serotonin reuptake inhibitors: analysis of achievable steady-state plasma
concentrations and the effect of ultrarapid metabolism at CYP2D6.
Pharmacotherapy 2002;22:1001-1006.
Lichtenstein AH, Appel LJ, Brands M et al. Diet and lifestyle recommendations
revision 2006: a scientific statement from the American Heart Association
Nutrition Committee. Circulation, 2006; 114: 82-96.
Lin CL, Lin JK. Epigallocatechin gallate (EGCG) attenuates high glucose-induced
insulin signaling blockade in human hepG2 hepatoma cells. Mol Nutr Food Res.
2008; 52(8): 930-9.
Liu H, Xiao Y, Xiong C, Wei A, Ruan J. Apoptosis induced by a new flavonoid in
human hepatoma HepG2 cells involves reactive oxygen species-mediated
mitochondrial dysfunction and MAPK activation. Eur J Pharmacol. 2011 Jan 15.
Madhyastha R, Madhyastha H, Nakajima Y, Omura S, Maruyama M. Curcumin
Facilitates Fibrinolysis and Cellular Migration during Wound Healing by
Modulating Urokinase Plasminogen Activator Expression. Pathophysiol Haemost
Thromb. 2010 Nov 12
Maheshwari A, Misro MM, Aggarwal A, Sharma RK, Nandan D. N-Acetyl-L-
cysteine counteracts oxidative stress and prevents H(2) O(2) induced germ cell
apoptosis through down-regulation of caspase-9 and JNK/c-Jun. Mol Reprod Dev.
2010 Dec 22. doi: 10.1002/mrd.21268.
Moon et al. Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation
of 3T3-L1 cells. Obesity (Silver Spring). 2007; 15(11): 2571-82.
Pan J, Xiao Q, Sheng CY, Hong Z, Yang HQ, Wang G, Ding JQ, Chen SD.
Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3)
attenuates dopaminergic neuronal damage in mouse model of Parkinson’s disease.
Neurochem Int. 2009 Jun;54(7):418-25. Epub 2009 Jan 29.
Ramerstorfer J, Furtmüller R, Sarto-Jackson I, Varagic Z, Sieghart W, Ernst M.
The GABAA Receptor {alpha}+{beta}- Interface: A Novel Target for Subtype
Selective Drugs. J Neurosci. 2011 Jan 19;31(3):870-7
Romier-Crouzet B, Van De Walle J, During A, Joly A, Rousseau C, Henry O,
Larondelle Y, Schneider YJ. Inhibition of inflammatory mediators by polyphenolic
plant extracts in human intestinal Caco-2 cells. Food Chem Toxicol. 2009
Jun;47(6):1221-30. Epub 2009 Feb 20.
Spiliotaki M, Salpeas V, Malitas P, Alevizos V, Moutsatsou P. Altered
glucocorticoid receptor signaling cascade in lymphocytes of bipolar disorder
patients. Psychoneuroendocrinology. 2006 Jul;31(6):748-60. Epub 2006 Apr 18.
Stornetta RL, Zhu JJ. Ras and Rap Signaling in Synaptic Plasticity and Mental
Disorders. Neuroscientist. 2010 Apr 29.
Tian H, Zhang G, Li H, Zhang Q. Antio
xidant NAC and AMPA/KA receptor
antagonist DNQX inhibited JNK3 activation following global ischemia in rat
hippocampus. Neurosci Res. 2003 Jun;46(2):191-7.
Waltner-Low ME et al. Epigallocatechin gallate, a constituent of green tea,
represses hepatic glucose production. J Biol Chem. 2002; 277(38): 34933-40.
Wu H et al. JNK-dependent NFATc1 pathway positively regulates IL-13 gene
expression induced by (-)-epigallocatechin-3-gallate in human basophilic KU812
cells. Free Radic Biol Med. 2009; 47(7): 1028-38.
Wu N et al. Taurine prevents free fatty acid-induced hepatic insulin resistance in
association with inhiditing JNK1 activation and improving insulin signaling in
vitro. Diabetes Res Clin Pract. 2010; 90(3): 288-90.
Xie N, Wang C, Lin Y, Li H, Chen L, Zhang T, Sun Y, Zhang Y, Yin D, Chi Z.
The role of p38 MAPK in valproic acid induced microglia apoptosis. Neurosci
Lett. 2010 Sep 20;482(1):51-6. Epub 2010 Jul 16.
Xu Y, Hou XY, Liu Y, Zong YY. Different protection of K252a and N-acetyl-L-
cysteine against amyloid-beta peptide-induced cortical neuron apoptosis involving
inhibition of MLK3-MKK7-JNK3 signal cascades. J Neurosci Res. 2009
Mar;87(4):918-27.
Yaniv SP, Lucki A, Klein E, Ben-Shachar D. Dexamethasone enhances the
norepinephrine-induced ERK/MAPK intracellular pathway possibly via
dysregulation of the alpha2-adrenergic receptor: implications for antidepressant
drug mechanism of action. Eur J Cell Biol. 2010 Sep;89(9):712-22.
Zhang F, Lau SS, Monks TJ. The Cytoprotective Effect of N-acetyl-L-cysteine
against ROS-induced Cytotoxicity is Independent of its Ability to Enhance
Glutathione Synthesis. Toxicol Sci. 2010 Dec 6.
REFERENCES
Bailey, L.B., Gregory, J.F., (1999).
“Polymorphisms of
methylenetetrahydrofolate
reductase and other enzymes: metabolic
significance, risks and impact on folate
requirement.” J Nutr 129(5): 919-22.
Bailey, L.B., Gregory, J.F., (1999).
“Folate metabolism and requirements.” J
Nutr 129(4): 779-82.
Basile, V.S., Masellis, M., Potkin, S.G.,
Kennedy, J.L., Pharmacogenomics in
schizophrenia: the quest for
individualized therapy. Hum Mol Genet.
2002 Oct 1;11(20):2517-30
Blaisdell, J., Mohrenweiser, H., Jackson,
Ferguson, J., Coulter, S., Chanas, S.,
Chanas, B., Xi, T., Ghanayem, B.,
Goldstein, J.A. Identification and
functional characterization of new potentially
defective alleles of human CYP2C19.
Pharmacogenetics. 2002 Dec;12(9):703-11.
Bosron, W.F., Ting-Kai, L., (1986).
“Genetic polymorphism of human liver
alcohol and aldehyde dehydrogenases,
and their relationship to alcohol
metabolism and alcoholism.” Hepatology 6(3): 502 –
510.
Bradford, L.D., CYP2D6 allele
frequency in European Caucasians,
Asians, Africans and their descendants.
Pharmacogenomics. 2002 Mar;3 (2):229-
43.
Brockmoller, J., et.al. Pharmacogenetic
diagnosis of cytochrome P450
polymorphisms in clinical drug
development and in drug treatment.
Pharmacogenetics. 2000:1:125-51.
Budziszewska B, Szymanska M,
Leskiewicz M, Basta-Kaim A, Jaworska-
Feil L, Kubera M, Jantas D, Lason W. The
decrease in JNK- and p38-MAP kinase
activity is accompanied by the enhancement of
PP2A phosphate level in the brain of
prenatally stressed rats. J Physiol
Pharmacol. 2010 Apr;61(2):207-15.
Carter CJ. Multiple genes and factors
associated with bipolar disorder
converge on growth factor and stress activated kinase
pathways controlling translation
initiation: implications for
oligodendrocyte viability. Neurochem
Int. 2007 Feb;50(3):461-90. Epub 2007 Jan 18.
Review.
Ceriello, A., Giugliano, D., Quatraro, A.,
Lefebvre, P.J., Anti-oxidants show an
anti-hypertensive effect in diabetic and
hypertensive subjects. Clin Sci
1991;81:739-42.
Chang, T.K., et al. Enhanced
cyclophosphamide and ifosfamide
activation in primary human hepatocyte cultures:
response to cytochrome P-450 inducers
and autoinduction by oxazaphosphorines.
Cancer Res 1997; 57(10):1946-54.
Chango, A., Boisson, F., et al. (2000).
“The effect of 677C-->T and 1298A-->C
mutations on plasma homocysteine and
5,10-methylenetetrahydrofolate
reductase activity in healthy subjects.” Br J Nutr
83(6): 593-6.
Charradi K, Sebai H, Elkahoui S, Ben
Hassine F, Limam F, Aouani E. Grape
Seed Extract Alleviates High-Fat Diet-Induced
Obesity and Heart Dysfunction by
Preventing Cardiac Siderosis. Cardiovasc
Toxicol. 2011 Jan 14.
Cheng, T., Zhu, Z., et al. (2001). “Effects
of multinutrient supplementation on
antioxidant defense systems in healthy
human beings.” J Nutr Biochem 12(7):
388-395.
Chida, M., Yokoi, T., Fukui, T.,
Kinoshita, M., Yokota, J., Kamataki, T.,
Detection of three genetic polymorphisms in the 5’-
flanking region and intron 1 of human
CYP1A2 in the Japanese population. Jpn
J Cancer Res. 1999 Sep;90(9):899-902
Chistyakov, D. A., Savost’anov, et al.
(2001). “Polymorphisms in the Mn-SOD
and EC-SOD genes and their relationship
to diabetic neuropathy in type 1 diabetes
mellitus.” BMC Med Genet 2(1): 4.
Cosma, G., Crofts, F., et al. (1993).
“Relationship between genotype and
function of the human CYP1A1 gene.” J Toxicol
Environ Health 40(2-3): 309-16.
Cozza, K.L., Armstrong, S.C.,
Oesterheld, J.R., Drug Interaction
principles for Medical Practice. American Psychiatric
Publishing Inc. (2003)
Chuang DM. Neuroprotective and
neurotrophic actions of the mood
stabilizer lithium: can it be used to treat
neurodegenerative diseases? Crit Rev
Neurobiol. 2004;16(1-2):83-90. Review.
Das J et al. Acetaminophen induced
acute liver failure via oxidative stress
and JNK activation: protective role of taurine by
the suppression of cytochrome P450
2E1. Free Radic Res. 2010; 44(3): 340-55.
Gao N, Budhraja A, Cheng S, Yao H,
Zhang Z, Shi X. Induction of apoptosis
in human leukemia cells by grape seed
extract occurs via activation of c-Jun
NH2-terminal kinase.
Clin Cancer Res. 2009 Jan 1;15(1):140-
9.
Ho, P.C., et al. Influence of CYP2C9
genotypes on the formation of a
hepatotoxic metabolite of valproic acid in human
liver microsomes. Pharmacogenomics J
2003; 3(6):335-42.
Jeong SW, Kim LS, Hur D, Bae WY,
Kim JR, Lee JH. Gentamicin-induced
spiral ganglion cell death: apoptosis mediated
by ROS and the JNK signaling pathway.
Acta Otolaryngol. 2010 Jun;130(6):670-
8.
Lam, Y.W.F., Gaedigk, A., Ereshefsy,
L., et al: CYP2D6 inhibition by selective
serotonin reuptake inhibitors: analysis of
achievable steady-state plasma
concentrations and the effect of
ultrarapid metabolism at CYP2D6.
Pharmacotherapy 2002;22:1001-1006.
Lichtenstein AH, Appel LJ, Brands M et
al. Diet and lifestyle recommendations
revision 2006: a scientific statement
from the American Heart Association
Nutrition Committee. Circulation, 2006;
114: 82-96.
Lin CL, Lin JK. Epigallocatechin gallate
(EGCG) attenuates high glucose-induced
insulin signaling blockade in human
hepG2 hepatoma cells. Mol Nutr Food
Res. 2008; 52(8): 930-9.
Liu H, Xiao Y, Xiong C, Wei A, Ruan J.
Apoptosis induced by a new flavonoid in
human hepatoma HepG2 cells involves
reactive oxygen species-mediated
mitochondrial dysfunction and MAPK
activation. Eur J Pharmacol. 2011 Jan
15.
Madhyastha R, Madhyastha H, Nakajima
Y, Omura S, Maruyama M. Curcumin
Facilitates Fibrinolysis and Cellular
Migration during Wound Healing by
Modulating Urokinase Plasminogen
Activator Expression. Pathophysiol
Haemost Thromb. 2010 Nov 12
Maheshwari A, Misro MM, Aggarwal A,
Sharma RK, Nandan D. N-Acetyl-L-
cysteine counteracts oxidative stress and
prevents H(2) O(2) induced germ cell
apoptosis through down-regulation of
caspase-9 and JNK/c-Jun. Mol Reprod
Dev. 2010 Dec 22. doi: 10.1002/mrd.21268.
Moon et al. Inhibitory effect of (-)-
epigallocatechin-3-gallate on lipid
accumulation of 3T3-L1 cells. Obesity
(Silver Spring).
2007; 15(11): 2571-82.
Pan J, Xiao Q, Sheng CY, Hong Z, Yang
HQ, Wang G, Ding JQ, Chen SD.
Blockade of the translocation and
activation of c-Jun N-terminal kinase 3
(JNK3) attenuates dopaminergic neuronal
damage in mouse model of Parkinson’s
disease. Neurochem Int. 2009 Jun;54(7):418-25.
Epub 2009 Jan 29.
Ramerstorfer J, Furtmüller R, Sarto-
Jackson I, Varagic Z, Sieghart W, Ernst
M. The GABAA Receptor malpha?+ebetaS-
Interface: A Novel Target for Subtype
Selective Drugs. J Neurosci. 2011 Jan
19;31(3):870-7
Romier-Crouzet B, Van De Walle J,
During A, Joly A, Rousseau C, Henry O,
Larondelle Y, Schneider YJ. Inhibition
of inflammatory mediators by
polyphenolic plant extracts in human intestinal Caco-2
cells. Food Chem Toxicol. 2009
Jun;47(6):1221-30. Epub 2009 Feb 20.
Spiliotaki M, Salpeas V, Malitas P,
Alevizos V, Moutsatsou P. Altered
glucocorticoid receptor signaling cascade
in lymphocytes of bipolar disorder
patients. Psychoneuroendocrinology.
2006 Jul;31(6):748-60. Epub 2006 Apr
18.
Stornetta RL, Zhu JJ. Ras and Rap
Signaling in Synaptic Plasticity and
Mental Disorders. Neuroscientist. 2010 Apr 29.
Tian H, Zhang G, Li H, Zhang Q. Antio
xidant NAC and AMPA/KA receptor
antagonist DNQX inhibited JNK3
activation following global ischemia in
rat hippocampus. Neurosci Res. 2003
Jun;46(2):191-7.
Waltner-Low ME et al. Epigallocatechin
gallate, a constituent of green tea,
represses hepatic glucose production. J
Biol Chem. 2002; 277(38): 34933-40.
Wu H et al. JNK-dependent NFATc1
pathway positively regulates IL-13 gene
expression induced by (-)-
epigallocatechin-3-gallate in human
basophilic KU812 cells. Free Radic Biol Med. 2009; 47(7):
1028-38.
Wu N et al. Taurine prevents free fatty
acid-induced hepatic insulin resistance in
association with inhiditing JNK1
activation and improving insulin
signaling in vitro. Diabetes Res Clin Pract. 2010;
90(3): 288-90.
Xie N, Wang C, Lin Y, Li H, Chen L,
Zhang T, Sun Y, Zhang Y, Yin D, Chi Z.
The role of p38 MAPK in valproic acid
induced microglia apoptosis. Neurosci
Lett. 2010 Sep 20;482(1):51-6. Epub
2010 Jul 16.
Xu Y, Hou XY, Liu Y, Zong YY.
Different protection of K252a and N-
acetyl-L-cysteine against amyloid-beta peptide-
induced cortical neuron apoptosis
involving inhibition of MLK3-MKK7-JNK3 signal
cascades. J Neurosci Res. 2009
Mar;87(4):918-27.
Yaniv SP, Lucki A, Klein E, Ben-
Shachar D. Dexamethasone enhances the
norepinephrine-induced ERK/MAPK
intracellular pathway possibly via
dysregulation of the alpha2-adrenergic
receptor: implications for antidepressant
drug mechanism of action. Eur J Cell
Biol. 2010 Sep;89(9):712-22.
Zhang F, Lau SS, Monks TJ. The
Cytoprotective Effect of N-acetyl-L-
cysteine against ROS-induced Cytotoxicity is
Independent of its Ability to Enhance
Glutathione Synthesis. Toxicol Sci. 2010
Dec 6.
