While investigating this unique gene and the function it has within the body when over stimulated, the withdrawal program for these drugs was developed. The over expression of the JNK gene leads to the side effects and health concerns for anyone using drugs in this group. The activation of the JNK gene can be reduced with specific supplements used in combination.

Below, I have listed the drugs and a short paragraph about the drug and the JNK gene as an example. You will also find 1 clinical trial backing the information. Only 1 clinical trial is listed per drug, however, there are hundreds that could have been used as a reference.

At some point in the future this information will be put in book form with all clinical trials listed. The use of the JNK supplement, supplement combination with these drugs, the reduction of JNK gene activation with these supplements  and the withdrawal program listed below is Patent Pending. Individuals may use this information freely for their own use. Any commercial use of this information is strictly prohibited by patent law. Physicians wishing to use this withdrawal program in their practice should contact The Road Back.

In the last sentence of each paragraph, I list the supplements that should be used for the withdrawal. All drugs include a supplement called JNK, Body Calm and Body Calm Supreme. Methamphetamine includes the addition of a type of vitamin E called tocotrienol. The tocotrienol needs to be one that is high in Delta made from the annatto bean.

You would take 1 packet of the JNK supplement in the morning each day and use Body Calm for mild daytime anxiety and mild insomnia and the Body Calm and Body calm Supreme for extreme daytime anxiety and extreme insomnia. You would take the Body Calm or the Body Calm Supreme during the daytime (1 or 2 capsules) every 2 to 4 hours. 

The JNK supplement will work quickly!

The JNK supplement, Body Calm and Body Calm Supreme are available at TRB Health or by calling 1-866-810-3809. 

If you are taking an opiate or pain medication as a prescription, consult your physician first.

Opiates

During initial use and during withdrawal, these drugs will over stimulate a gene called JNK. The over activation of the JNK gene will cause neuronal cell death and neurotoxicity.  The cascading effect will also be low levels of glutathione and high oxidative stress. (1) Suggested supplements with opiate taper would be: JNK, Body Calm and Body Calm Supreme. 

Methamphetamine is thought to be the most lethal drug causing neurotoxicity. Meth will induce an increase in JNK activity and this effect is directly related to cell death. (2) Suggested supplements would be JNK, tocotrienol vitamin E with high Delta, Body Calm and Body Calm Supreme for anxiety and sleep issues. 

Cocaine

Chronic exposure to cocaine activates a stress response, which activates the over expression of the JNK gene. The activation of the JNK gene by cocaine leads to the behavioral alteration. (3) Suggested supplements would be JNK, Body Calm and Body Calm Supreme.

Marijuana

Tetrahydrocannabinol (THC), the major active component of marijuana, induces the activation of JNK. (4) Suggested supplements would be JNK, Body Calm and Body Calm Supreme.

Alcohol 

The effect on alcohol throughout the body is widely accepted as fact this century. The liver as well as the brain take a heavy toll with chronic alcohol consumption. The activation of the JNK gene by alcohol plays a detrimental role with the body. With diabetes being common with chronic alcohol use, it is not a surprise since the activation of the JNK precedes insulin sensitivity. (5) Suggested supplements would be JNK, Body Calm and Body Calm Supreme.

Heroin 

Heroin falls in the opiate classification regarding the activation of the JNK gene and neurotoxicity and the same supplements would be used. (1) Suggested supplements would be JNK, Body Calm and Body Calm Supreme. 

(1)  Neuroscience. 2003;122(4):997-1002.
Chronic morphine treatment and withdrawal induce up-regulation of c-Jun N-terminal kinase 3 gene expression in rat brain.

(2) Toxicology. 2008 Apr 18;246(2-3):234-41. Epub 2008 Feb 6.
Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells.

(3)  Neuropharmacology. 2010 Jul-Aug;59(1-2):100-6. Epub 2010 Apr 22.
Activation of c-Jun N-terminal kinase is required for the regulation of endoplasmic reticulum stress response in the rat dorsal striatum following repeated cocaine administration.

(4)  Mol Pharmacol. 2000 Oct;58(4):814-20.
The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase.

(5)  Free Radic Biol Med. 2009 Sep 1;47(5):518-28. Epub 2009 May 27.
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase.